Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rolipram. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A known ✓ | P27815 | 19/20 | 0.98 |
| ▸ | PDE4B known ✓ | Q07343 | 12/20 | 0.98 |
| ▸ | PDE4C known ✓ | Q08493 | 11/20 | 0.98 |
| ▸ | PDE4D known ✓ | Q08499 | 11/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | VEGFA | P15692 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | MAPT | P10636 | 1/20 | 0.98 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | PDE5A | O76074 | 1/20 | 0.98 |
| ▸ | TNF | P01375 | 1/20 | 0.98 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.98 |
| ▸ | BLM | P54132 | 1/20 | 0.98 |
| ▸ | PDE1A | P54750 | 1/20 | 0.98 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rolipram SCHEMBL29360376 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| S-Rolipram SCHEMBL29475409 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| (-)-Rolipram SCHEMBL29598924 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Rolipram SCHEMBL27930 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| (-)-Rolipram SCHEMBL576805 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Rolipram SCHEMBL3719855 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| S-Rolipram SCHEMBL5321568 | 0.99 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3544304 | 0.98 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| Rolipram SCHEMBL28973411 | 0.98 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DCYP3A4 | |
| SCHEMBL3554826 | 0.98 | PDE4A (0.98) | PDE4APDE4BPDE4CPDE4DCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140350035-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR- ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-8877758-B2 | Combinations of medicaments, containing PDE4-inhibitors and EP4-receptor-antagonists | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-04 | — | — | US | disclosed |
| US-20130237527-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-09-12 | — | — | US | disclosed |
| US-20130225609-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140350035-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR- ANTAGONISTS | PTGER4, PTGER1, PDE4A | PDE4A 3/4885PDE4B 10/4885PDE4C 21/4885 |
| US-20130225609-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS | PTGER4, PTGER1, PDE4A | PDE4A 3/4885PDE4B 10/4885PDE4C 21/4885 |
| US-20130237527-A1 | COMBINATIONS OF MEDICAMENTS, CONTAINING PDE4-INHIBITORS AND EP4-RECEPTOR-ANTAGONISTS | PTGER4, PTGER1, PTGER3 | PDE4A 7/4885PDE4B 18/4885PDE4C 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.