Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15210437 | 0.93 | FYN (0.46) | FYNPDE4CPOLBPRMT5WDR77 | |
| SCHEMBL15210436 | 0.93 | FYN (0.46) | FYNPDE4CPOLBPRMT5WDR77 | |
| SCHEMBL15210650 | 0.92 | FYN (0.44) | FYNPDE4CPOLBJAK2JAK1 | |
| SCHEMBL15210396 | 0.92 | FYN (0.44) | FYNPDE4CPOLBJAK2JAK1 | |
| SCHEMBL15210397 | 0.92 | FYN (0.44) | FYNPDE4CPOLBJAK2JAK1 | |
| SCHEMBL725156 | 0.90 | FYN (0.49) | FYNPDE4CPOLBNPC1HPGD | |
| SCHEMBL15210575 | 0.89 | FYN (0.40) | FYNPDE4CPOLBJAK2JAK1 | |
| SCHEMBL15210545 | 0.87 | FYN (0.44) | FYNPDE4CPOLBJAK2JAK1 | |
| SCHEMBL723443 | 0.86 | FYN (0.58) | FYNPDE4CPOLBJAK2JAK1 | |
| SCHEMBL15210570 | 0.86 | FYN (0.44) | FYNPDE4CJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2817313-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | claimed |
| US-20150038527-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | US | claimed |
| EP-2817313-A1 | FUROPYRIDINE DERIVATIVES | Merck Patent GmbH (DE) | 2014-12-31 | — | — | EP | claimed |
| WO-2013124025-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | claimed |
| EP-2817313-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | disclosed |
| EP-2817313-B1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-07 | — | — | EP | disclosed |
| US-20150038527-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | US | disclosed |
| US-20150038527-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | US | disclosed |
| WO-2013124025-A1 | FUROPYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038527-A1 | FUROPYRIDINE DERIVATIVES | SYK, LYN, BTK | FYN 31/4885PDE4C 3343/4885POLB 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.