Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 11/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 10/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3384299 | 0.88 | HDAC1 (1.00) | HDAC8HDAC1HDAC6 | |
| SCHEMBL1520902 | 0.88 | HDAC8 (0.78) | HDAC8HDAC1 | |
| SCHEMBL3380502 | 0.86 | HDAC8 (0.76) | HDAC8HDAC1 | |
| SCHEMBL13039739 | 0.84 | HDAC1 (0.73) | HDAC8HDAC1HDAC6 | |
| SCHEMBL3380367 | 0.84 | HDAC1 (0.72) | HDAC8HDAC1HDAC6 | |
| SCHEMBL13039738 | 0.83 | HDAC1 (0.70) | HDAC8HDAC1HDAC6 | |
| SCHEMBL13039733 | 0.83 | HDAC1 (0.70) | HDAC8HDAC1HDAC6 | |
| SCHEMBL1520800 | 0.79 | HDAC1 (0.66) | HDAC8HDAC1 | |
| SCHEMBL12649829 | 0.78 | HDAC1 (0.63) | HDAC8HDAC1 | |
| SCHEMBL3383995 | 0.77 | HDAC1 (0.63) | HDAC8HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160015693-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | AGENCY SCIENCE TECH & RES (SG) | 2016-01-21 | — | — | US | disclosed |
| US-8969313-B2 | Methods and compounds for preventing and treating a tumour | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-03-03 | — | — | US | disclosed |
| US-20110053882-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2011-03-03 | — | — | US | disclosed |
| EP-1280764-B1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC (CA) | 2010-11-24 | — | — | EP | disclosed |
| EP-2217240-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | Agency for Science, Technology And Research (SG) | 2010-08-18 | — | — | EP | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | METHYLGENE INC. | 2009-07-16 | — | — | US | disclosed |
| WO-2009058102-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2009-05-07 | — | — | WO | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-7288567-B2 | Inhibitors of histone deacetylase | METHYLGENE INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| EP-1524262-A1 | Inhibitors of histone deacetylase | Methylgene, Inc. (CA) | 2005-04-20 | — | — | EP | disclosed |
| EP-1280764-A2 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2003-02-05 | — | — | EP | disclosed |
| US-20020115826-A1 | Inhibitors of histone deacetylase | 92229129 QUEBEC INC. (CA) | 2002-08-22 | — | — | US | disclosed |
| WO-2001070675-A2 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE, INC. (CA) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110053882-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | HDAC1, CCAR2, HDAC11 | HDAC8 19/4885HDAC1 1/4885HDAC6 25/4885 |
| US-20020115826-A1 | Inhibitors of histone deacetylase | HDAC1, HDAC5, HDAC3 | HDAC8 9/4885HDAC1 1/4885HDAC6 6/4885 |
| US-20160015693-A1 | METHODS AND COMPOUNDS FOR PREVENTING AND TREATING A TUMOUR | HDAC1, HDAC11, CCAR2 | HDAC8 15/4885HDAC1 1/4885HDAC6 24/4885 |
| US-20090181971-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC3 | HDAC8 9/4885HDAC1 1/4885HDAC6 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.