Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYBB | P04839 | 1/20 | 1.00 |
| ▸ | USP7 | Q93009 | 2/20 | 0.85 |
| ▸ | HPN | P05981 | 2/20 | 0.84 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.79 |
| ▸ | GAPDH | P04406 | 1/20 | 0.62 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.62 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.62 |
| ▸ | CD44 | P16070 | 1/20 | 0.62 |
| ▸ | MSN | P26038 | 1/20 | 0.62 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.62 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.62 |
| ▸ | AR | P10275 | 2/20 | 0.48 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | GRK6 | P43250 | 1/20 | 0.47 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.47 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31277265 | 1.00 | CYBB (1.00) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL16406028 | 0.92 | USP7 (1.00) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL2031914 | 0.91 | HPN (1.00) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL14979491 | 0.91 | CYBB (0.84) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL16406027 | 0.91 | CYBB (0.84) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL15213460 | 0.91 | CYBB (0.83) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL25602307 | 0.90 | USP7 (0.87) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL13856206 | 0.89 | NR4A1 (1.00) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL18134628 | 0.89 | CYBB (0.79) | CYBBUSP7HPNNR4A1GAPDH | |
| SCHEMBL15213476 | 0.86 | USP7 (0.77) | CYBBUSP7HPNNR4A1GAPDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9567347-B2 | Use of small molecule inhibitors targeting the interaction between RAC GTPase and p67(phox) | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2017-02-14 | — | — | US | disclosed |
| US-20160297835-A1 | USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67(PHOX) | CHILDREN'S HOSPITAL MEDICAL CENTER | 2016-10-13 | — | — | US | disclosed |
| US-9453022-B2 | Use of small molecule inhibitors targeting the interaction between Rac GTPase and p67 (phox) | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2016-09-27 | — | — | US | disclosed |
| US-9334284-B2 | — | — | 2016-05-10 | — | — | US | disclosed |
| US-20150025067-A1 | USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67 (PHOX) | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2015-01-22 | — | — | US | disclosed |
| WO-2013123081-A2 | USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67 (PHOX) | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2013-08-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160297835-A1 | USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67(PHOX) | RAC1, ARHGDIB, NOXO1 | CYBB 49/4885USP7 547/4885HPN 2261/4885 |
| US-20150025067-A1 | USE OF SMALL MOLECULE INHIBITORS TARGETING THE INTERACTION BETWEEN RAC GTPASE AND P67 (PHOX) | RAC1, ARHGDIB, NOXO1 | CYBB 49/4885USP7 547/4885HPN 2261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.