Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 3/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 14/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | HPD | P32754 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12712848 | 0.95 | PSEN1 (0.35) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL15214167 | 0.91 | PSEN1 (0.34) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL15214168 | 0.89 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12712847 | 0.86 | PSEN1 (0.35) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL8080412 | 0.86 | PSEN1 (0.46) | F11KLKB1PSEN1PSEN2APH1B | |
| SCHEMBL12712856 | 0.84 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15214165 | 0.83 | PSEN1 (0.36) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15214175 | 0.82 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15214162 | 0.80 | PSEN1 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL12712837 | 0.79 | PSEN1 (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518975-B2 | Gamma secretase modulators | Merck Sharp + Dohme Corp. (US) | 2013-08-27 | — | — | US | disclosed |