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SCHEMBL15214844

SCHEMBL15214844

CCCCCC1CCC(c2ccc(-c3ccc(C(=O)Nc4ccc(-c5cc6c7c(c8c(c6cc5OC)OC(c5ccccc5)(c5ccc(OC)cc5)C=C8)C(C)(C)c5c-7cc(C(F)(F)F)cc5C(F)(F)F)c(C)c4)cc3)cc2)CC1

nearest known ligand 0.33

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MTTP P55157 3/20 0.33
▸ SMO Q99835 1/20 0.33
▸ RAF1 P04049 1/20 0.32
▸ BRAF P15056 1/20 0.32
▸ GCGR P47871 1/20 0.31
▸ GIPR P48546 1/20 0.31
▸ MCHR1 Q99705 1/20 0.30
▸ DGAT1 O75907 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1960109 1.00 MTTP (0.33) MTTPSMORAF1BRAFGCGR
SCHEMBL1961362 0.98 SMO (0.33) MTTPSMORAF1BRAFGCGR
SCHEMBL9972773 0.98 SMO (0.33) MTTPSMORAF1BRAFGCGR
SCHEMBL1963225 0.98 MTTP (0.32) MTTPSMORAF1BRAFGCGR
SCHEMBL9973069 0.98 MTTP (0.32) MTTPSMORAF1BRAFGCGR
SCHEMBL12553418 0.96 MTTP (0.31) MTTPSMODGAT1
SCHEMBL12553415 0.96 RAF1 (0.31) SMORAF1BRAF
SCHEMBL1962042 0.96 RAF1 (0.31) SMORAF1BRAF
SCHEMBL9973011 0.96 PLG (0.32) SMORAF1BRAFGCGRGIPR
SCHEMBL1964161 0.96 PLG (0.32) SMORAF1BRAFGCGRGIPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3045971-A1 PHOTOCHROMIC COMPOUNDS AND COMPOSITIONS Transitions Optical, Inc. (US) 2016-07-20 — — EP disclosed
US-8518546-B2 Photochromic compounds and compositions TRANSITIONS OPTICAL, INC. (US) 2013-08-27 — — US disclosed