Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 5/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.48 |
| ▸ | BRAF | P15056 | 6/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.48 |
| ▸ | SRC | P12931 | 3/20 | 0.48 |
| ▸ | AXL | P30530 | 2/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 2/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | ACOX3 | O15254 | 1/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521800 | 0.91 | ABL1 (0.51) | ABL1MAPK14BRAFMAPK11SRC | |
| SCHEMBL1521813 | 0.90 | MAPK14 (0.46) | MAPK14BRAFMAPK11DDR2FGFR4 | |
| SCHEMBL1521944 | 0.83 | ABL1 (0.54) | ABL1MAPK14BRAFMAPK11SRC | |
| SCHEMBL1521654 | 0.80 | MAPK14 (0.47) | ABL1MAPK14BRAFMAPK11FGFR4 | |
| SCHEMBL1521615 | 0.79 | FGFR4 (0.42) | ABL1MAPK14BRAFSRCEPHB4 | |
| SCHEMBL2079924 | 0.76 | ABL1 (0.72) | ABL1MAPK14BRAFMAPK11SRC | |
| SCHEMBL1521760 | 0.76 | TNK2 (0.47) | ABL1MAPK14SRCEPHB4LCK | |
| SCHEMBL1521641 | 0.75 | TNK2 (0.48) | ABL1BRAFSRCEPHB4FGFR4 | |
| SCHEMBL2082233 | 0.73 | MAPK14 (0.70) | ABL1MAPK14BRAFMAPK11SRC | |
| SCHEMBL12079460 | 0.73 | BRAF (0.64) | ABL1MAPK14BRAFMAPK11SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110118271-A1 | Kinase Inhibitors Useful For The Treatment Of Proliferative Diseases | FLYNN DANIEL L | 2011-05-19 | — | — | US | disclosed |
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090099190-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110118271-A1 | Kinase Inhibitors Useful For The Treatment Of Proliferative Diseases | BRAF, PRKDC, RAF1 | ABL1 936/4885MAPK14 240/4885BRAF 1/4885 |
| US-20090099190-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | BRAF, PRKDC, RAF1 | ABL1 936/4885MAPK14 240/4885BRAF 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.