Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 11/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | BMX | P51813 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | FES | P07332 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521723 | 0.87 | FGFR4 (0.66) | FGFR4FGFR1KDRFGFR3KIT | |
| SCHEMBL1521532 | 0.87 | FGFR4 (0.50) | FGFR4BMXABL1TNK2MAP4K2 | |
| SCHEMBL1521505 | 0.84 | FGFR4 (0.40) | FGFR4FGFR1KDRFGFR3KIT | |
| SCHEMBL1521503 | 0.80 | FGFR4 (0.39) | FGFR4FGFR1KDRFGFR3KIT | |
| SCHEMBL1521677 | 0.78 | FGFR1 (0.38) | FGFR4FGFR1KDRFGFR3KIT | |
| SCHEMBL1521384 | 0.76 | FGFR1 (0.37) | FGFR4FGFR1KDRFGFR3KIT | |
| SCHEMBL1521763 | 0.75 | ABL1 (0.43) | FGFR1KDRFGFR3KITBMX | |
| SCHEMBL1521729 | 0.73 | FGFR4 (0.49) | FGFR4FGFR1KDRFGFR3KIT | |
| SCHEMBL1521434 | 0.73 | FGFR4 (0.38) | FGFR4FGFR1KDRFGFR3PDGFRB | |
| SCHEMBL1522002 | 0.73 | FGFR4 (0.49) | FGFR4FGFR1FGFR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | disclosed |
| US-20090099190-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2009-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099190-A1 | Kinase inhibitors useful for the treatment of proliferative diseases | BRAF, PRKDC, RAF1 | FGFR4 1073/4885FGFR1 577/4885KDR 500/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.