Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13679280 | 0.82 | — | — | |
| SCHEMBL181688 | 0.80 | TSHR (0.46) | TSHRMAPT | |
| SCHEMBL8012334 | 0.78 | TSHR (0.44) | TSHRMAPT | |
| SCHEMBL467228 | 0.78 | TSHR (0.44) | TSHRMAPT | |
| SCHEMBL439461 | 0.78 | TSHR (0.39) | TSHRMAPTCHRM1AKR1A1CHRM3 | |
| SCHEMBL14041325 | 0.77 | — | — | |
| SCHEMBL17024432 | 0.75 | TSHR (0.46) | TSHRMAPTCHRM1AKR1A1CHRM3 | |
| SCHEMBL14646595 | 0.75 | RNPEP (0.31) | — | |
| SCHEMBL301262 | 0.75 | MAPT (0.55) | TSHRMAPTCHRM1AKR1A1CHRM3 | |
| SCHEMBL1198338 | 0.75 | MAPT (0.55) | TSHRMAPTCHRM1AKR1A1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066659-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |