Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 16/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 16/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 16/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 16/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 16/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 16/20 | 0.52 |
| ▸ | APP | P05067 | 3/20 | 0.47 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493248 | 0.92 | PSEN1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL702183 | 0.85 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5128567 | 0.82 | BDKRB1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13007708 | 0.81 | PSEN1 (0.55) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4118802 | 0.81 | BDKRB1 (0.54) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4403417 | 0.79 | BDKRB1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL15267613 | 0.79 | PSEN1 (0.52) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4123662 | 0.77 | PSEN1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13587282 | 0.77 | PSEN1 (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13587102 | 0.76 | PSEN1 (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066659-B1 | SUBSTITUTED SULFONAMIDE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2013-08-28 | — | — | EP | disclosed |