Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.56 |
| ▸ | MAPK12 | P53778 | 13/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.56 |
| ▸ | MAPK11 | Q15759 | 12/20 | 0.56 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521998 | 0.91 | MAPK14 (0.56) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL1522050 | 0.90 | MAPK14 (0.45) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL5065364 | 0.88 | MAPK14 (0.53) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL5062510 | 0.82 | KCNJ6 (0.49) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL5057475 | 0.81 | BRAF (0.52) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL4563409 | 0.81 | MAPK14 (0.53) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL4429207 | 0.80 | ABL1 (0.55) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL1521892 | 0.80 | MAPK14 (0.55) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL4425259 | 0.80 | MAPK14 (0.52) | MAPK14MAPK12MAPK13MAPK11BRAF | |
| SCHEMBL1521999 | 0.80 | MAPK14 (0.52) | MAPK14MAPK12MAPK13MAPK11BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7897762-B2 | Kinase inhibitors useful for the treatment of proliferative diseases | DECIPHERA PHARMACEUTICALS, LLC (US) | 2011-03-01 | — | — | US | claimed |