⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11955052 | 0.92 | TSHR (0.46) | — | |
| SCHEMBL14002143 | 0.89 | TSHR (0.43) | — | |
| SCHEMBL12933281 | 0.89 | TSHR (0.43) | — | |
| SCHEMBL14907 | 0.81 | — | — | |
| SCHEMBL13617233 | 0.79 | TSHR (0.40) | — | |
| SCHEMBL8851469 | 0.78 | — | — | |
| SCHEMBL6648740 | 0.78 | TSHR (0.43) | — | |
| SCHEMBL12707552 | 0.78 | TSHR (0.43) | — | |
| SCHEMBL26318516 | 0.76 | TSHR (0.48) | — | |
| SCHEMBL26535341 | 0.75 | TSHR (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110272514-A | A kind of brominated isobutylene-p-methylstyrene copolymer and preparation method thereof | 黄河三角洲京博化工研究院有限公司 | 2019-09-24 | — | — | CN | claimed |
| CN-105601779-A | Process for direct halogenation of poly(p-methyl styrene-CO-isobutylene) prepared with solution method | BEIJING INSTITUTE PETROCHEMICAL TECHNOLOGY | 2016-05-25 | — | — | CN | claimed |
| CN-1225648-A | Process for halogenation of isomonoolefin/para-alkylstyrene copolymers | EXXON CHEMICAL PATENTS INC (US) | 1999-08-11 | — | — | CN | claimed |
| CN-1225649-A | Improved process for halogenating isomonoolefin copolymers | EXXON CHEMICAL PATENTS INC (US) | 1999-08-11 | — | — | CN | claimed |
| US-20230372537-A1 | LIPID NANOPARTICLE FORMULATIONS | ACUITAS THERAPEUTICS INC (CA) | 2023-11-23 | — | — | US | disclosed |
| US-11795170-B2 | Therapeutic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2023-10-24 | — | — | US | disclosed |
| US-11771715-B2 | Circular RNA compositions and methods | ORNA THERAPEUTICS, INC. (US) | 2023-10-03 | — | — | US | disclosed |
| US-11766449-B2 | Circular RNA compositions and methods | ORNA THERAPEUTICS, INC. (US) | 2023-09-26 | — | — | US | disclosed |
| US-11712481-B2 | Lipid nanoparticle formulations | Acuitas Therapeutics, Inc. (CA) | 2023-08-01 | — | — | US | disclosed |
| US-20230235365-A1 | ENGINEERED RETRONS AND METHODS OF USE | RENAGADE THERAPEUTICS MANAGEMENT INC. (US) | 2023-07-27 | — | — | US | disclosed |
| US-20230226096-A1 | CIRCULAR RNA COMPOSITIONS AND METHODS | ORNA THERAPEUTICS, INC. | 2023-07-20 | — | — | US | disclosed |
| US-11679120-B2 | Circular RNA compositions and methods | ORNA THERAPEUTICS, INC. (US) | 2023-06-20 | — | — | US | disclosed |
| US-7442718-B2 | Inhibitors of aspartyl protease | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-10-28 | — | — | US | disclosed |
| US-20070149569-A1 | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2007-06-28 | — | — | US | disclosed |
| US-20070149569-A1 | Methods of treating amyloidosis using cyclopropyl derivative aspartyl protease inhibitors | ELAN PHARMACEUTICALS, INC. | 2007-06-28 | — | — | US | disclosed |
| WO-2007047305-A1 | METHODS OF TREATING AMYLOIDOSIS USING CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007047305-A1 | METHODS OF TREATING AMYLOIDOSIS USING CYCLOPROPYL DERIVATIVE ASPARTYL PROTEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| EP-1754705-A2 | Antagonists for treatment of CD11/CD18 adhesion receptor mediated disorders | Genentech, Inc. (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1053220-B1 | IMPROVED SEPARATION PROCESSES | UNION CARBIDE CHEM PLASTIC (US) | 2005-02-23 | — | — | EP | disclosed |
| CN-1225648-A | Process for halogenation of isomonoolefin/para-alkylstyrene copolymers | EXXON CHEMICAL PATENTS INC (US) | 1999-08-11 | — | — | CN | disclosed |