Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 4/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15218878 | 0.95 | STK4 (0.45) | STK4PLK1PLK2PRKDCSMN1; SMN2 | |
| SCHEMBL15218881 | 0.89 | STK4 (0.54) | STK4PLK1PLK2PRKDCSMN1; SMN2 | |
| SCHEMBL15218910 | 0.89 | STK4 (0.54) | STK4PLK1PLK2SMN1; SMN2 | |
| SCHEMBL15218884 | 0.88 | STK4 (0.41) | STK4PLK1PLK2PRKDCSMN1; SMN2 | |
| SCHEMBL15218904 | 0.87 | STK4 (0.45) | STK4PLK1PLK2 | |
| SCHEMBL21492031 | 0.86 | STK4 (0.52) | STK4PLK1PLK2SMN1; SMN2 | |
| SCHEMBL15218893 | 0.83 | STK4 (0.40) | STK4PLK1PLK2PRKDCSMN1; SMN2 | |
| SCHEMBL15218905 | 0.83 | STK4 (0.42) | STK4PLK1PLK2SMN1; SMN2 | |
| SCHEMBL30744603 | 0.83 | STK4 (0.42) | STK4PLK1PLK2SMN1; SMN2 | |
| SCHEMBL15218902 | 0.81 | MTOR (0.35) | STK4PRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958918-B1 | DIHYDROPTERIDINONES II | BOEHRINGER INGELHEIM INT (DE) | 2016-12-07 | — | — | EP | disclosed |
| US-8865716-B2 | Dihydropteridinones II | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-21 | — | — | US | disclosed |
| US-8865716-B2 | Dihydropteridinones II | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-10-21 | — | — | US | disclosed |
| WO-2014127816-A1 | DIHYDROPTERIDINONES II | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-08-28 | — | — | WO | disclosed |
| US-20130225593-A1 | DIHYDROPTERIDINONES II | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-29 | — | — | US | disclosed |
| US-20130225593-A1 | DIHYDROPTERIDINONES II | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225593-A1 | DIHYDROPTERIDINONES II | BACE1, BACE2, APP | STK4 790/4885PLK1 2390/4885PLK2 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.