Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.39 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | CD63 | P08962 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 7/20 | 0.35 |
| ▸ | JAK3 | P52333 | 6/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.32 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.32 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.32 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.32 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.32 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.32 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22305 | 0.88 | SYK (0.41) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15207446 | 0.86 | JAK2 (0.42) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL19869 | 0.86 | SYK (0.39) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL21617 | 0.86 | SYK (0.38) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL21236 | 0.86 | JAK2 (0.45) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL21199 | 0.85 | SYK (0.41) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL15208049 | 0.85 | JAK2 (0.40) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL20134 | 0.83 | SYK (0.36) | SYKEIF2AK4JAK2JAK3PTK2 | |
| SCHEMBL20159 | 0.81 | SCN9A (0.42) | SYKEIF2AK4CD63JAK2JAK3 | |
| SCHEMBL15206594 | 0.80 | SYK (0.59) | SYKEIF2AK4CD63JAK2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023851-B2 | Triazolopyrazine derivatives | MERCK PATENT GMBH (DE) | 2015-05-05 | — | — | US | disclosed |
| US-20130225568-A1 | TRIAZOLOPYRAZINE DERIVATIVES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225568-A1 | TRIAZOLOPYRAZINE DERIVATIVES | SYK, IRAK1, ZAP70 | SYK 1/4885EIF2AK4 1898/4885CD63 2804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.