Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | CNR2 | P34972 | 7/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16114842 | 0.87 | MEN1 (0.56) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL7894643 | 0.87 | MEN1 (0.56) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL14943683 | 0.86 | MEN1 (0.55) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL12401203 | 0.84 | MEN1 (0.54) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL12482254 | 0.83 | POLB (0.54) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL16115275 | 0.78 | CNR2 (0.54) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL15338732 | 0.78 | SYK (0.52) | — | |
| SCHEMBL7895956 | 0.76 | CNR2 (0.56) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL19099236 | 0.75 | POLB (0.63) | MEN1KMT2ACNR2POLBALDH1A1 | |
| SCHEMBL14701618 | 0.75 | POLB (0.63) | MEN1KMT2ACNR2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2631238-A1 | Spirocyclic inhibitors of serine proteases for the treatment of hcv infections | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-08-28 | — | — | EP | disclosed |