Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | MTOR | P42345 | 6/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.45 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.45 |
| ▸ | PRKDC | P78527 | 6/20 | 0.45 |
| ▸ | SRC | P12931 | 5/20 | 0.45 |
| ▸ | ABL1 | P00519 | 4/20 | 0.45 |
| ▸ | HCK | P08631 | 4/20 | 0.45 |
| ▸ | KDR | P35968 | 4/20 | 0.45 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.45 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.41 |
| ▸ | ITK | Q08881 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15220890 | 0.94 | EGFR (0.46) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL15490995 | 0.84 | EGFR (0.49) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL19562034 | 0.83 | EGFR (0.47) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL16525928 | 0.81 | EGFR (0.45) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL15490957 | 0.81 | EGFR (0.43) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL15487195 | 0.80 | EGFR (0.52) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL15490976 | 0.79 | EGFR (0.42) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL19991475 | 0.79 | EGFR (0.45) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL15220968 | 0.78 | EGFR (0.43) | EGFRMTORHDAC1PIK3CDPIK3CA | |
| SCHEMBL15221103 | 0.78 | EGFR (0.43) | EGFRMTORHDAC1PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3037424-B1 | NOVEL QUINOLINE-SUBSTITUTED COMPOUND | TAIHO PHARMACEUTICAL CO LTD (JP) | 2017-11-08 | — | — | EP | disclosed |
| EP-2722332-B1 | QUINOLYLPYRROLOPYRIMIDYL FUSED-RING COMPOUND OR SALT THEREOF | TAIHO PHARMACEUTICAL CO LTD (JP) | 2016-04-20 | — | — | EP | disclosed |
| EP-2722332-A1 | QUINOLYLPYRROLOPYRIMIDYL FUSED-RING COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2014-04-23 | — | — | EP | disclosed |
| WO-2013125709-A1 | QUINOLYLPYRROLOPYRIMIDYL FUSED-RING COMPOUND OR SALT THEREOF | 大鵬薬品工業株式会社 (JP) | 2013-08-29 | — | — | WO | disclosed |