Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 4/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 17/20 | 0.46 |
| ▸ | FLT3 | P36888 | 8/20 | 0.45 |
| ▸ | KIT | P10721 | 6/20 | 0.45 |
| ▸ | LCK | P06239 | 5/20 | 0.45 |
| ▸ | FLT1 | P17948 | 5/20 | 0.45 |
| ▸ | FLT4 | P35916 | 5/20 | 0.45 |
| ▸ | CSF1R | P07333 | 4/20 | 0.45 |
| ▸ | FRK | P42685 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.44 |
| ▸ | BLK | P51451 | 4/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.44 |
| ▸ | LYN | P07948 | 3/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15221826 | 0.91 | KDR (0.56) | AURKBAURKACDK19KDRFLT3 | |
| SCHEMBL276101 | 0.91 | FLT3 (0.51) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL15222000 | 0.89 | NTRK1 (0.40) | AURKAKDRFLT3KITLCK | |
| SCHEMBL275542 | 0.88 | FLT3 (0.55) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL15222003 | 0.87 | KDR (0.47) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL15221839 | 0.86 | KDR (0.46) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL15222001 | 0.85 | KDR (0.44) | AURKBAURKAKDRFLT3KIT | |
| SCHEMBL15221833 | 0.83 | KDR (0.53) | AURKBAURKACDK19KDRFLT3 | |
| SCHEMBL15221869 | 0.83 | KDR (0.55) | AURKBAURKACDK19KDRFLT3 | |
| SCHEMBL15221868 | 0.82 | KDR (0.54) | AURKBAURKACDK19KDRFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130225809-A1 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | BAYER HEALTHCARE LLC (US) | 2013-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130225809-A1 | PYRROLOTRIAZINE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH ANGIOGENESIS | MKI67, TK2, CDK4 | AURKB 2267/4885AURKA 1525/4885CDK19 655/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.