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SCHEMBL15224050

SCHEMBL15224050

CC(=O)c1cc2cc(C(=O)N(C)CCN(C)C)[nH]c2[nH]1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HRH4 Q9H3N8 5/20 0.59
▸ SYK P43405 2/20 0.40
▸ HRH3 Q9Y5N1 1/20 0.36
▸ ITGB3 P05106 1/20 0.36
▸ ITGA2B P08514 1/20 0.36
▸ HTR2C P28335 1/20 0.35
▸ RXFP1 Q9HBX9 2/20 0.35
▸ ATM Q13315 1/20 0.35
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ PARP1 P09874 1/20 0.34
▸ F10 P00742 1/20 0.34
▸ AR P10275 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12392435 0.84 HRH4 (0.55) HRH4SYKHRH3ITGB3ITGA2B
SCHEMBL16329496 0.83 HRH4 (0.51) HRH4SYKHRH3ITGB3ITGA2B
SCHEMBL15224044 0.78 HRH4 (0.49) HRH4SYKHRH3ITGB3ITGA2B
SCHEMBL12392422 0.78 HRH4 (0.49) HRH4SYKHRH3ITGB3ITGA2B
SCHEMBL15623147 0.76 HRH4 (0.53) HRH4HRH3ITGB3ITGA2BHTR2C
SCHEMBL15223911 0.76 HRH4 (0.63) HRH4HRH3ITGB3ITGA2BHTR2C
SCHEMBL15223908 0.76 HRH4 (0.70) HRH4HRH3ITGB3ITGA2BHTR2C
SCHEMBL12289144 0.70 HRH4 (0.69) HRH4HRH3ITGB3ITGA2BHTR2C
SCHEMBL12392431 0.68 HRH4 (0.66) HRH4HRH3ITGB3ITGA2BHTR2C
SCHEMBL12848228 0.67 HRH4 (0.49) HRH4HRH3ITGB3ITGA2BHTR2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170333567-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers SYNTARGA BV (NL) 2017-11-23 — — US disclosed
US-9815784-B2 CC-1065 analogs and their conjugates SYNTARGA B.V. (NL) 2017-11-14 — — US disclosed
US-20170274090-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers SYNTARGA BV (NL) 2017-09-28 — — US disclosed
US-9629924-B2 Conjugates of CC-1065 analogs and bifunctional linkers SYNTARGA BV (NL) 2017-04-25 — — US disclosed
US-20130224227-A1 NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS BYONDIS B.V. (NL) 2013-08-29 — — US disclosed
US-20110207767-A1 Novel cc-1065 Analogs and Their Conjugates BYONDIS B.V. (NL) 2011-08-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170274090-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers PCNA, DCLRE1A, CDC5L HRH4 2715/4885SYK 2286/4885HRH3 1777/4885
US-20170333567-A1 Novel Conjugates of CC-1065 Analogs and Bifunctional Linkers PCNA, DCLRE1A, CDC5L HRH4 2715/4885SYK 2286/4885HRH3 1777/4885
US-20110207767-A1 Novel cc-1065 Analogs and Their Conjugates PCNA, CDC5L, TOP1 HRH4 3266/4885SYK 1746/4885HRH3 2452/4885
US-20130224227-A1 NOVEL CONJUGATES OF CC-1065 ANALOGS AND BIFUNCTIONAL LINKERS PCNA, DCLRE1A, CDC5L HRH4 2715/4885SYK 2286/4885HRH3 1777/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.