Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.67 |
| ▸ | BACE2 | Q9Y5Z0 | 9/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.61 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.61 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.61 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.61 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.61 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917444 | 1.00 | BACE1 (0.67) | BACE1BACE2CYP2D6PSEN1PSEN2 | |
| SCHEMBL11982768 | 1.00 | BACE1 (0.67) | BACE1BACE2CYP2D6PSEN1PSEN2 | |
| SCHEMBL11967169 | 1.00 | BACE1 (0.67) | BACE1BACE2CYP2D6PSEN1PSEN2 | |
| SCHEMBL6916607 | 0.90 | BACE1 (0.67) | BACE1BACE2 | |
| SCHEMBL6917196 | 0.90 | BACE1 (0.67) | BACE1BACE2CYP2D6 | |
| SCHEMBL11967123 | 0.89 | BACE1 (0.65) | BACE1BACE2CYP2D6 | |
| SCHEMBL6918198 | 0.88 | BACE1 (0.64) | BACE1BACE2CYP2D6 | |
| SCHEMBL11982780 | 0.88 | BACE1 (0.79) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL11967140 | 0.88 | BACE1 (0.79) | BACE1BACE2PSEN1PSEN2APH1B | |
| SCHEMBL2108761 | 0.88 | BACE1 (0.76) | BACE1BACE2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079914-B2 | Fused aminodihydro-oxazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-07-14 | — | — | US | disclosed |
| US-9079914-B2 | Fused aminodihydro-oxazine derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-07-14 | — | — | US | disclosed |
| EP-2653473-A1 | Fused Aminodihydro-Oxazine Derivatives | Eisai R&D Management Co., Ltd. (JP) | 2013-10-23 | — | — | EP | disclosed |
| EP-2456774-B1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |
| EP-2456774-B1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |