Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6917983 | 0.89 | BACE1 (0.38) | BACE1BACE2KCNH2 | |
| SCHEMBL6916532 | 0.89 | BACE1 (0.38) | BACE1BACE2KCNH2 | |
| SCHEMBL15338540 | 0.89 | BACE1 (0.38) | BACE1BACE2KCNH2 | |
| SCHEMBL15224832 | 0.81 | BACE1 (0.55) | BACE1BACE2 | |
| SCHEMBL16887902 | 0.81 | BACE1 (0.36) | BACE1BACE2 | |
| SCHEMBL6918197 | 0.79 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL15225384 | 0.79 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL6917936 | 0.79 | BACE1 (0.45) | BACE1BACE2 | |
| SCHEMBL11902356 | 0.77 | BACE1 (0.42) | BACE1BACE2 | |
| SCHEMBL8514726 | 0.76 | BACE1 (0.33) | BACE1BACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2653473-A1 | Fused Aminodihydro-Oxazine Derivatives | Eisai R&D Management Co., Ltd. (JP) | 2013-10-23 | — | — | EP | disclosed |
| EP-2456774-B1 | FUSED AMINODIHYDRO-OXAZINE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2013-09-04 | — | — | EP | disclosed |