Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.44 |
| ▸ | MET | P08581 | 13/20 | 0.44 |
| ▸ | HSPB1 | P04792 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3560489 | 0.91 | KDR (0.47) | KDRMETHSPB1ALDH1A1MAPT | |
| SCHEMBL27811860 | 0.89 | KDR (0.47) | KDRMETHSPB1ALDH1A1MAPT | |
| SCHEMBL3566289 | 0.88 | KDR (0.44) | KDRMETHSPB1ALDH1A1MAPT | |
| SCHEMBL13168660 | 0.88 | KDR (0.44) | KDRMETHSPB1ALDH1A1MAPT | |
| SCHEMBL3573701 | 0.86 | KDR (0.55) | KDRMETALDH1A1MAPTMAPK1 | |
| SCHEMBL3566451 | 0.85 | KDR (0.55) | KDRMETHSPB1ALDH1A1MAPT | |
| SCHEMBL14771341 | 0.83 | KDR (0.47) | KDRMETFLT1 | |
| SCHEMBL307973 | 0.83 | KDR (0.47) | KDRMETHSPB1ALDH1A1MAPT | |
| SCHEMBL3562646 | 0.83 | KDR (0.48) | KDRMETFLT1 | |
| SCHEMBL3562636 | 0.83 | KDR (0.48) | KDRMETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781664-B1 | INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING | METHYLGENE INC (CA) | 2013-09-04 | — | — | EP | disclosed |