Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 6/20 | 0.66 |
| ▸ | ADK | P55263 | 5/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.48 |
| ▸ | ADA | P00813 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873435 | 1.00 | ADORA2A (0.66) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL18200214 | 1.00 | ADORA2A (0.66) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL14544819 | 1.00 | ADORA2A (0.66) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL474796 | 1.00 | ADORA2A (0.66) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL14429140 | 0.93 | ADORA2A (0.57) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL3229703 | 0.90 | ADORA2A (0.67) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL24837545 | 0.88 | ADORA2A (0.65) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL474780 | 0.88 | ADORA2A (0.65) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL474664 | 0.88 | ADORA2A (0.65) | ADORA2AADKADORA3ADORA1ADORA2B | |
| SCHEMBL12151837 | 0.88 | ADORA2A (0.65) | ADORA2AADKADORA3ADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421879-B1 | NOVEL 7-DEAZAPURINE NUCLEOSIDES FOR THERAPEUTIC USES | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 2013-09-04 | — | — | EP | disclosed |