Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 16/20 | 0.32 |
| ▸ | CDK2 | P24941 | 16/20 | 0.32 |
| ▸ | CDK9 | P50750 | 16/20 | 0.32 |
| ▸ | CDK1 | P06493 | 15/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 15/20 | 0.32 |
| ▸ | CDK7 | P50613 | 14/20 | 0.32 |
| ▸ | CCNH | P51946 | 14/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 7/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 7/20 | 0.32 |
| ▸ | CCND1 | P24385 | 7/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.31 |
| ▸ | GRM8 | O00222 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 2/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL370079 | 0.81 | GRM4 (0.48) | GRM4 | |
| SCHEMBL15303390 | 0.72 | GRM4 (0.38) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL16243055 | 0.68 | GRM4 (0.35) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL370558 | 0.67 | GRM4 (0.66) | CCNT1CDK2CDK9CDK1CCNB1 | |
| SCHEMBL370433 | 0.63 | GRM4 (0.44) | GRM4 | |
| SCHEMBL360900 | 0.61 | GRM4 (0.43) | GRM4 | |
| SCHEMBL15182523 | 0.60 | GRM4 (0.36) | CDK4GRM4CDK6 | |
| SCHEMBL15182650 | 0.59 | GRM4 (0.49) | GRM4GRM8 | |
| SCHEMBL365689 | 0.59 | GRM4 (0.40) | GRM4 | |
| SCHEMBL370371 | 0.59 | GRM4 (0.40) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130252944-A1 | NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP. | 2013-09-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130252944-A1 | NOVEL FUSED PYRAZOLE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | GRM4, GRM1, GRM3 | CCNT1 4542/4885CDK2 2136/4885CDK9 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.