Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 12/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1528448 | 0.81 | PIK3CA (0.46) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL12611463 | 0.80 | PIK3CD (0.43) | PIK3CDPIK3CA | |
| SCHEMBL16550524 | 0.79 | PIK3CA (0.44) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL1528067 | 0.78 | PIK3CA (0.51) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL12611457 | 0.78 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL1528665 | 0.78 | PIK3CA (0.41) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL1528156 | 0.78 | PIK3CA (0.43) | PIK3CDPIK3CA | |
| SCHEMBL1485363 | 0.77 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CG | |
| SCHEMBL1528293 | 0.77 | PIK3CA (0.42) | PIK3CDPIK3CA | |
| SCHEMBL16550492 | 0.77 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483278-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011036280-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |