Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1528191 | 0.80 | KDM4C (0.43) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL5823357 | 0.73 | MEN1 (0.47) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL1485194 | 0.72 | MEN1 (0.37) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL4774063 | 0.70 | MEN1 (0.55) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL2738489 | 0.69 | MEN1 (0.51) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL4173315 | 0.69 | MEN1 (0.48) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL1485146 | 0.69 | KDM4C (0.36) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL14971389 | 0.68 | MEN1 (0.50) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL3230862 | 0.68 | MEN1 (0.50) | KDM4CNPC1RAB9AL3MBTL1MEN1 | |
| SCHEMBL15686649 | 0.68 | MEN1 (0.50) | KDM4CNPC1RAB9AL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483278-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. Hoffmann-La Roche AG (CH) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011036280-A1 | BENZOXAZEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-03-31 | — | — | WO | disclosed |