Nafoxidine

Nafoxidine

SCHEMBL153125

COc1ccc2c(c1)CCC(c1ccccc1)=C2c1ccc(OCCN2CCCC2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
EBP Q15125 1/20 1.00
SIGMAR1 Q99720 1/20 1.00
ESR1 P03372 14/20 0.61
ESR2 Q92731 10/20 0.61
LTA4H P09960 2/20 0.56
HRH3 Q9Y5N1 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nafoxidine SCHEMBL10563464 1.00 EBP (1.00) EBPSIGMAR1ESR1ESR2LTA4H
Nafoxidine SCHEMBL29494604 1.00 EBP (1.00) EBPSIGMAR1ESR1ESR2LTA4H
Nafoxidine SCHEMBL115778 0.99 EBP (0.98) EBPSIGMAR1ESR1ESR2LTA4H
Nafoxidine SCHEMBL8430193 0.99 EBP (0.98) EBPSIGMAR1ESR1ESR2LTA4H
Nafoxidine SCHEMBL29562423 0.99 EBP (0.98) EBPSIGMAR1ESR1ESR2LTA4H
SCHEMBL8015672 0.94 EBP (0.88) EBPSIGMAR1ESR1ESR2LTA4H
SCHEMBL2811903 0.94 EBP (0.88) EBPSIGMAR1ESR1ESR2LTA4H
SCHEMBL2811811 0.93 EBP (0.86) EBPSIGMAR1ESR1ESR2LTA4H
SCHEMBL13350303 0.93 EBP (0.86) EBPSIGMAR1ESR1ESR2LTA4H
SCHEMBL2817373 0.93 EBP (0.86) EBPSIGMAR1ESR1ESR2LTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 5407 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230346800-A1 REDUCTION OF THE INCIDENCE OR RECURRENCE OF BREAST CANCER IN POSTMENOPAUSAL WOMEN TREATED WITH INTRAVAGINAL SEX STEROID PRECURSOR ENDORECHERCHE, INC. (CA) 2023-11-02 US claimed
US-20230338355-A1 NK ANTAGONISTS FOR CONTRACEPTION ACER THERAPEUTICS INC. 2023-10-26 US claimed
EP-2796112-B2 Degradable implantable medical devices ELIXIR MEDICAL CORP (US) 2023-08-09 EP claimed
US-11690852-B2 Reduction of the incidence or recurrence of breast cancer in postmenopausal women treated with intravaginal sex steroid precursor ENDORECHERCHE. INC. 2023-07-04 US claimed
EP-4157242-A1 COMBINATION CANCER THERAPY WITH PENTAAZA MACROCYCLIC RING COMPLEX AND HORMONE THERAPY AGENT Galera Labs, LLC (US) 2023-04-05 EP claimed
WO-2023012353-A1 COMPOUNDS FOR USE IN THE THERAPEUTIC TREATMENT OF BATTEN DISEASE FONDAZIONE TELETHON (IT) 2023-02-09 WO claimed
US-20220313703-A1 REDUCTION OF THE INCIDENCE OR RECURRENCE OF BREAST CANCER IN POSTMENOPAUSAL WOMEN TREATED WITH INTRAVAGINAL SEX STEROID PRECURSOR ENDORECHERCHE, INC. (CA) 2022-10-06 US claimed
US-20220249413-A1 SWELL 1 MODULATORS FOR TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE, IMMUNE DEFICIENCIES, MALE INFERTILITY AND VASCULAR DISEASES UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) 2022-08-11 US claimed
CN-114514021-A SWELL1 modulators for the treatment of non-alcoholic fatty liver disease, immunodeficiency, male infertility, and vascular disease 爱荷华大学研究基金会 2022-05-17 CN claimed
EP-3982944-A1 SWELL 1 MODULATORS FOR TREATMENT OF NON-ALCOHOLIC FATTY LIVER DISEASE, IMMUNE DEFICIENCIES, MALE INFERTILITY AND VASCULAR DISEASES University of Iowa Research Foundation (US) 2022-04-20 EP claimed
WO-1995026720-A1 PERMANENTLY IONIC DERIVATIVES OF STEROID HORMONES AND THEIR ANTAGONISTS PHARMOS CORPORATION (US) 1995-10-12 WO claimed
WO-1995011013-A2 COMBINATION OF PROGESTERONE ANTAGONISTS AND ANTI-OESTROGENS WITH PARTIAL AGONISTIC ACTION FOR USE IN HORMONE-REPLACEMENT THERAPY FOR PERI- AND POST-MENOPAUSAL WOMEN SCHERING AKTIENGESELLSCHAFT (DE) 1995-04-27 WO claimed
WO-1995005828-A1 PROGESTERONE-ANTAGONISTIC AND ANTI-OESTROGEN COMPOUNDS FOR THE THERAPY OF LEIOMYOMATA UTERI SCHERING AKTIENGESELLSCHAFT (DE) 1995-03-02 WO claimed
EP-0246654-B1 Use of a sulfated polysaccharide DAIICHI SEIYAKU CO (JP) 1993-11-10 EP claimed
EP-0178862-B1 ANTIESTROGEN THERAPY FOR SYMPTOMS OF ESTROGEN DEFICIENCY BCM Technologies, INC. (US) 1993-08-04 EP claimed
US-4900815-A Sulfated polysaccharide DS4152 DAIICHI SEIYAKU CO., LTD. (JP) 1990-02-13 US claimed
US-4894373-A CLOMIPHEN, ISOMERS AND SALTS BCM TECHNOLOGIES, INC. (US) 1990-01-16 US claimed
US-4729999-A MENOPAUSE, SIDE EFFECT PREVENTION BCM TECHNOLOGIES (US) 1988-03-08 US claimed
EP-0246654-A2 Use of a sulfated polysaccharide DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1987-11-25 EP claimed
EP-0178862-A2 Antiestrogen therapy for symptoms of estrogen deficiency BCM Technologies, INC. (US) 1986-04-23 EP claimed