Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 20/20 | 0.69 |
| ▸ | CCR5 | P51681 | 1/20 | 0.62 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.62 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14666715 | 0.92 | CCR4 (0.82) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL185718 | 0.92 | CCR4 (0.82) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL15314748 | 0.86 | CCR4 (0.85) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL186405 | 0.86 | CCR4 (0.85) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10235347 | 0.86 | CCR4 (0.88) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10279001 | 0.84 | CCR4 (0.88) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10278957 | 0.84 | CCR4 (0.88) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL15314749 | 0.83 | CCR4 (0.68) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL358574 | 0.83 | CCR4 (0.90) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL186395 | 0.82 | CCR4 (0.79) | CCR4CCR5FFAR4SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401270-B1 | PYRAZOLE DERIVATIVES USED AS CCR4 RECEPTOR ANTAGONISTS | GLAXO GROUP LTD (GB) | 2013-10-16 | — | — | EP | disclosed |