Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 13/20 | 0.65 |
| ▸ | VEGFA | P15692 | 11/20 | 0.65 |
| ▸ | CNR1 | P21554 | 2/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL272935 | 0.79 | EGLN1 (1.00) | EGLN1VEGFACNR1CNR2HTT | |
| SCHEMBL15255387 | 0.75 | EGLN1 (0.70) | EGLN1VEGFACNR1CNR2HTT | |
| SCHEMBL14900099 | 0.75 | EGLN1 (0.69) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL15314777 | 0.74 | CNR2 (0.42) | EGLN1VEGFACNR1CNR2KDM4E | |
| SCHEMBL17340665 | 0.73 | EGLN1 (0.53) | EGLN1VEGFACNR2HTTKDM4E | |
| SCHEMBL12598814 | 0.71 | EGLN1 (0.68) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL278202 | 0.71 | VEGFA (1.00) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL12598863 | 0.71 | EGLN1 (0.63) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL273037 | 0.70 | EGLN1 (0.87) | EGLN1VEGFAHTTKDM4ETP53 | |
| SCHEMBL272116 | 0.69 | VEGFA (0.85) | EGLN1VEGFAHTTKDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2952192-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2015-12-09 | — | — | EP | disclosed |
| EP-2649998-B1 | Prolyl hydroxylase inhibitors | AERPIO THERAPEUTICS INC (US) | 2015-03-04 | — | — | EP | disclosed |
| EP-2649998-A1 | Prolyl hydroxylase inhibitors | Aerpio Therapeutics Inc. (US) | 2013-10-16 | — | — | EP | disclosed |