Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | MGAM | O43451 | 3/20 | 0.34 |
| ▸ | GUSB | P08236 | 2/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | GLB1 | P16278 | 1/20 | 0.31 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15315427 | 0.80 | GBA1 (0.34) | GAAMGAMGUSBGBA1GLB1 | |
| SCHEMBL15317989 | 0.80 | GUSB (0.35) | GAAGUSBGBA1GLB1 | |
| SCHEMBL8438017 | 0.80 | GUSB (0.35) | GAAGUSBGBA1GLB1 | |
| SCHEMBL19903790 | 0.79 | GUSB (0.31) | GUSB | |
| SCHEMBL14505206 | 0.77 | GLB1 (0.41) | GAAMGAMGUSBGBA1GLB1 | |
| SCHEMBL15315425 | 0.77 | GLB1 (0.41) | GAAMGAMGUSBGBA1GLB1 | |
| SCHEMBL14504119 | 0.77 | GLB1 (0.41) | GAAMGAMGUSBGBA1GLB1 | |
| SCHEMBL8259417 | 0.73 | ATM (0.35) | — | |
| SCHEMBL23841639 | 0.70 | GAA (0.32) | GAAMGAM | |
| SCHEMBL15436690 | 0.70 | GAA (0.32) | GAAMGAM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871778-B2 | Substituted pyrimidine compounds and their use as SYK inhibitors | GENOSCO (US) | 2014-10-28 | — | — | US | disclosed |
| US-20130274242-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | Genosco Inc. | 2013-10-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130274242-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE AS SYK INHIBITORS | SYK, BTK, LCK | GAA 725/4885MGAM 2280/4885GUSB 3688/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.