Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 2/20 | 1.00 |
| ▸ | JAK3 | P52333 | 6/20 | 0.74 |
| ▸ | AKT2 | P31751 | 2/20 | 0.71 |
| ▸ | GSK3B | P49841 | 2/20 | 0.71 |
| ▸ | KIT | P10721 | 1/20 | 0.71 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | JAK2 | O60674 | 2/20 | 0.60 |
| ▸ | AKT1 | P31749 | 1/20 | 0.58 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.58 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.58 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.58 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.58 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.58 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.58 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | BTK | Q06187 | 3/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1531444 | 1.00 | DOT1L (1.00) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL1531446 | 1.00 | DOT1L (1.00) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL15178732 | 0.92 | DOT1L (0.85) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL10074309 | 0.92 | DOT1L (0.85) | DOT1LJAK3AKT2GSK3BKIT | |
| Hydrochloric Acid SCHEMBL15170166 | 0.90 | DOT1L (0.82) | DOT1LJAK3AKT2GSK3BKIT | |
| Hydrochloric Acid SCHEMBL15169727 | 0.90 | DOT1L (0.82) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL12612313 | 0.86 | DOT1L (0.74) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL2019326 | 0.85 | DOT1L (0.74) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL3954391 | 0.85 | JAK3 (1.00) | DOT1LJAK3AKT2GSK3BKIT | |
| SCHEMBL20862485 | 0.85 | JAK3 (1.00) | DOT1LJAK3AKT2GSK3BKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9029359-B2 | Heteroaryl Btk inhibitors | BIOGEN IDEC MA, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| EP-2485589-A1 | HETEROARYL BTK INHIBITORS | Biogen Idec MA Inc. (US) | 2012-08-15 | — | — | EP | disclosed |
| US-20120157442-A1 | HETEROARYL BTK INHIBITORS | SUNESIS PHARMACEUTICALS, INC. (US) | 2012-06-21 | — | — | US | disclosed |
| WO-2011029043-A1 | HETEROARYL BTK INHIBITORS | BIOGEN IDEC MA INC. (US) | 2011-03-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120157442-A1 | HETEROARYL BTK INHIBITORS | BTK, LYN, SYK | DOT1L 1876/4885JAK3 99/4885AKT2 329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.