Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 16/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 17/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 13/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331560 | 0.90 | PIK3CD (0.58) | PIK3CGPIK3CDPIK3CBPIK3CALMNA | |
| SCHEMBL15320419 | 0.86 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2720069 | 0.80 | PIK3CD (0.62) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL2720113 | 0.77 | PIK3CD (0.66) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL19331481 | 0.76 | PIK3CD (0.56) | PIK3CGPIK3CD | |
| SCHEMBL6122226 | 0.76 | PIK3CD (0.66) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL15302942 | 0.74 | PIK3CD (0.82) | PIK3CGPIK3CDPIK3CBPIK3CA | |
| SCHEMBL15319861 | 0.74 | PIK3CD (0.55) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL15302945 | 0.74 | PIK3CD (0.82) | PIK3CGPIK3CDPIK3CBPIK3CA | |
| SCHEMBL19331513 | 0.74 | PIK3CD (0.56) | PIK3CGPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2834231-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013152150-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2013-10-10 | — | — | WO | disclosed |