Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 18/20 | 1.00 |
| ▸ | EGFR | P00533 | 18/20 | 0.83 |
| ▸ | STK4 | Q13043 | 3/20 | 0.83 |
| ▸ | SRC | P12931 | 3/20 | 0.83 |
| ▸ | KDR | P35968 | 3/20 | 0.83 |
| ▸ | STK25 | O00506 | 2/20 | 0.83 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.83 |
| ▸ | GAK | O14976 | 2/20 | 0.83 |
| ▸ | STK17B | O94768 | 2/20 | 0.83 |
| ▸ | STK10 | O94804 | 2/20 | 0.83 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.83 |
| ▸ | ABL1 | P00519 | 2/20 | 0.83 |
| ▸ | LCK | P06239 | 2/20 | 0.83 |
| ▸ | FYN | P06241 | 2/20 | 0.83 |
| ▸ | FES | P07332 | 2/20 | 0.83 |
| ▸ | CSF1R | P07333 | 2/20 | 0.83 |
| ▸ | YES1 | P07947 | 2/20 | 0.83 |
| ▸ | LYN | P07948 | 2/20 | 0.83 |
| ▸ | MET | P08581 | 2/20 | 0.83 |
| ▸ | HCK | P08631 | 2/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15320643 | 1.00 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR | |
| SCHEMBL24037452 | 0.93 | ERBB2 (0.89) | ERBB2EGFRSTK4SRCKDR | |
| SCHEMBL9883172 | 0.91 | ERBB2 (0.87) | ERBB2EGFRSTK4SRCKDR | |
| Neratinib SCHEMBL29394766 | 0.91 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR | |
| SCHEMBL2130964 | 0.91 | ERBB2 (0.86) | ERBB2EGFRSTK4SRCKDR | |
| Neratinib SCHEMBL29801657 | 0.91 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR | |
| Neratinib SCHEMBL571763 | 0.91 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR | |
| Neratinib SCHEMBL15163654 | 0.91 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR | |
| Neratinib SCHEMBL15163655 | 0.91 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR | |
| Neratinib SCHEMBL571762 | 0.91 | ERBB2 (1.00) | ERBB2EGFRSTK4SRCKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2833886-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HangzhouDeRenYuCheng Biotechnology Ltd. (CN) | 2015-02-11 | — | — | EP | claimed |
| WO-2013152135-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | ZHANG DAWEI (US) | 2013-10-10 | — | — | WO | claimed |
| US-9353062-B2 | Substituted quinolines as bruton's tyrosine kinases inhibitors | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2016-05-31 | — | — | US | disclosed |
| US-20150057312-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HANGZHOUDERENYUCHENG BIOTECHNOLOGY LTD (CN) | 2015-02-26 | — | — | US | disclosed |
| EP-2833886-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | HangzhouDeRenYuCheng Biotechnology Ltd. (CN) | 2015-02-11 | — | — | EP | disclosed |
| WO-2013152135-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | ZHANG DAWEI (US) | 2013-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150057312-A1 | SUBSTITUTED QUINOLINES AS BRUTON'S TYROSINE KINASES INHIBITORS | BTK, ABL1, LYN | ERBB2 206/4885EGFR 1627/4885STK4 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.