Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Threonine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY4R | P50391 | 2/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Arginine SCHEMBL15324499 | 0.88 | OTC (0.38) | NPY4RNPY1R | |
| Arginine SCHEMBL15322928 | 0.87 | OTC (0.35) | NPY4RNPY1R | |
| Threonine SCHEMBL285577 | 0.82 | NPY4R (0.36) | NPY4RNPY1R | |
| Arginine SCHEMBL15322472 | 0.81 | OTC (0.39) | NPY4RNPY1R | |
| Arginine SCHEMBL15322527 | 0.80 | OTC (0.42) | — | |
| Arginine SCHEMBL15322526 | 0.80 | OTC (0.42) | — | |
| Arginine SCHEMBL7929056 | 0.80 | OTC (0.43) | — | |
| Arginine SCHEMBL30517755 | 0.80 | OTC (0.43) | — | |
| SCHEMBL25300066 | 0.80 | NPY4R (0.39) | NPY4RNPY1R | |
| SCHEMBL446930 | 0.80 | NPY4R (0.39) | NPY4RNPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836832-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155458-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |