Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glutamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 known ✓ | P35228 | 11/20 | 0.42 |
| ▸ | NOS1 known ✓ | P29475 | 7/20 | 0.42 |
| ▸ | NOS3 known ✓ | P29474 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | BLM | P54132 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | GRM8 | O00222 | 1/20 | 0.47 |
| ▸ | GRM6 | O15303 | 1/20 | 0.47 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | GSR | P00390 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutamine SCHEMBL15322948 | 1.00 | KMT2A (0.66) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL3059857 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL20553625 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL14485584 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL6555864 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL4613452 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL5085797 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL104313 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL5848376 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 | |
| Glutamine SCHEMBL3688684 | 0.89 | KMT2A (0.83) | KMT2ABLMALOX15PMP22CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836832-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155458-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |