Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | SIK1 | P57059 | 2/20 | 0.40 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.40 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12656931 | 0.93 | KDR (0.60) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL12656674 | 0.91 | KDR (0.62) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL1532389 | 0.91 | KDR (0.52) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL12627041 | 0.90 | KDR (0.51) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL12627040 | 0.90 | KDR (0.51) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL1815909 | 0.90 | KDR (0.51) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL12627044 | 0.86 | KDR (0.47) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL1532268 | 0.86 | KDR (0.58) | KDRFLT3KITSIK1SIK2 | |
| SCHEMBL1532247 | 0.85 | KDR (0.44) | KDR | |
| SCHEMBL12627061 | 0.85 | KDR (0.46) | KDRFLT3KITSIK1SIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2478361-A2 | PROTEIN KINASE CONJUGATES AND INHIBITORS | Avila Therapeutics, Inc. (US) | 2012-07-25 | — | — | EP | disclosed |
| WO-2011034907-A2 | PROTEIN KINASE CONJUGATES AND INHIBITORS | AVILA THERAPEUTICS, INC. (US) | 2011-03-24 | — | — | WO | disclosed |