Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Creatinine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Creatinine SCHEMBL15323293 | 0.90 | CRBN (0.40) | CRBN | |
| Creatinine SCHEMBL15323575 | 0.88 | KDM4E (0.36) | CRBN | |
| Creatinine SCHEMBL21404094 | 0.87 | CRBN (0.45) | CRBN | |
| Creatinine SCHEMBL15323323 | 0.86 | CRBN (0.37) | CRBN | |
| Creatinine SCHEMBL15323472 | 0.84 | CRBN (0.33) | CRBN | |
| Creatinine SCHEMBL17873936 | 0.81 | CRBN (0.45) | CRBN | |
| Creatinine SCHEMBL15323676 | 0.80 | CRBN (0.36) | CRBN | |
| Creatinine SCHEMBL15323175 | 0.79 | — | — | |
| Creatinine SCHEMBL15323326 | 0.79 | CRBN (0.33) | CRBN | |
| Creatinine SCHEMBL15323589 | 0.79 | CRBN (0.40) | CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836833-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155456-A1 | PRENATAL SCREENING FOR DOWN SYNDROME AND TRISOMY 18 | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |