Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.56 |
| ▸ | BHMT | Q93088 | 10/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.46 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.46 |
| ▸ | BHMT2 | Q9H2M3 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 3/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.40 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.39 |
| ▸ | GRM8 | O00222 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL15323684 | 1.00 | SLC7A5 (0.56) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL15323403 | 0.94 | SLC7A5 (0.64) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL15323407 | 0.94 | SLC7A5 (0.64) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL23924432 | 0.92 | SLC7A5 (0.67) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL9714739 | 0.92 | SLC7A5 (0.67) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL1352748 | 0.92 | SLC7A5 (0.67) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL1352746 | 0.92 | SLC7A5 (0.67) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL15323179 | 0.90 | SLC7A5 (0.49) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL15323183 | 0.90 | SLC7A5 (0.49) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 | |
| Leucine SCHEMBL10439303 | 0.89 | SLC7A5 (0.58) | SLC7A5BHMTSLC1A3SLC1A2BHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836832-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | Wayne State University (US) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013155458-A1 | EARLY TRIMESTER SCREENING FOR EARLY- AND LATE-ONSET PREECLAMPSIA | WAYNE STATE UNIVERSITY (US) | 2013-10-17 | — | — | WO | disclosed |