⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28122099 | 1.00 | — | — | |
| SCHEMBL19244485 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL29256547 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL28553654 | 0.91 | EPHX1 (0.41) | — | |
| SCHEMBL872685 | 0.89 | EPHX1 (0.44) | — | |
| SCHEMBL872686 | 0.89 | EPHX1 (0.44) | — | |
| SCHEMBL20856638 | 0.89 | EPHX1 (0.44) | — | |
| SCHEMBL19244484 | 0.89 | EPHX1 (0.44) | — | |
| SCHEMBL8624367 | 0.88 | PLG (0.34) | — | |
| SCHEMBL9179955 | 0.88 | PLG (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2837629-B1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | ASYMCHEM LABORATORIES (TIANJIN) CO LTD (CN) | 2017-03-22 | — | — | EP | disclosed |
| US-9371326-B2 | Method for synthesizing sapropterin dihydrochloride | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2016-06-21 | — | — | US | disclosed |
| US-9371326-B2 | Method for synthesizing sapropterin dihydrochloride | ASYMCHEM LABORATORIES (TIANJIN) CO., LTD (CN) | 2016-06-21 | — | — | US | disclosed |
| US-20150119573-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD (CN) | 2015-04-30 | — | — | US | disclosed |
| US-20150119573-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | TIANJIN ASYMCHEM PHARMACEUTICAL CO., LTD (CN) | 2015-04-30 | — | — | US | disclosed |
| EP-2837629-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | Asymchem Laboratories (Tianjin) Co., Ltd (CN) | 2015-02-18 | — | — | EP | disclosed |
| WO-2013152608-A1 | METHOD FOR SYNTHESIZING SAPROPTERIN DIHYDROCHLORIDE | 凯莱英医药集团（天津）股份有限公司 (CN) | 2013-10-17 | — | — | WO | disclosed |