⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2770773 | 0.71 | — | — | |
| SCHEMBL3073245 | 0.68 | — | — | |
| SCHEMBL11234 | 0.68 | — | — | |
| SCHEMBL1059359 | 0.67 | — | — | |
| SCHEMBL746126 | 0.66 | — | — | |
| SCHEMBL4370451 | 0.66 | — | — | |
| SCHEMBL135967 | 0.66 | — | — | |
| SCHEMBL7698086 | 0.66 | — | — | |
| SCHEMBL27637323 | 0.65 | — | — | |
| SCHEMBL28136559 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4660198-B2 | — | — | 2011-03-30 | — | — | JP | claimed |
| US-20100105714-A1 | Furanone Compounds and Methods of Making and Using The Same | BIOGEN IDEC MA INC. (US) | 2010-04-29 | — | — | US | claimed |
| US-20100035918-A1 | Imidazolone Compounds and Methods of Making and Using the Same | BIOGEN IDEC MA INC (US) | 2010-02-11 | — | — | US | claimed |
| EP-2121669-A2 | FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | Biogen Idec MA, Inc. (US) | 2009-11-25 | — | — | EP | claimed |
| EP-2108017-A2 | IMIDAZOLONE COMPOUNDS AS TGF-BETA FAMILY TYPE I RECEPTORS, ALK5 AND/OR ALK4 ANTAGONISTS | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | claimed |
| WO-2009009059-A1 | SPIRO COMPOUNDS AS ANTAGONISTS OF TGF-BETA | BIOGEN IDEC MA INC. (US) | 2009-01-15 | — | — | WO | claimed |
| WO-2008094556-A2 | IMIDAZOLONE COMPOUNDS AS TGF-BETA FAMILY TYPE I RECEPTORS, ALK5 AND/OR ALK4 ANTAGONISTS | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | claimed |
| WO-2008094574-A2 | FURANONE COMPOUNDS AND METHODS OF MAKING AND USING THE SAME | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | claimed |
| EP-1578425-B1 | SUBSTITUTED 1-PIPERIDIN-3-YL-4-PIPERIDIN-4-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2007-11-21 | — | — | EP | claimed |
| EP-1786802-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | Biogen Idec MA, Inc. (US) | 2007-05-23 | — | — | EP | claimed |
| US-20060252747-A1 | Substitituted 1-piperidin-3-yl-piperidin 4-yl-piperazine derivatives and their use as neurokinin auantagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-09 | — | — | US | claimed |
| JP-2006512348-A | — | — | 2006-04-13 | — | — | JP | claimed |
| US-20060063809-A1 | Tri-substituted heteroaryls and methods of making and using the same | BIOGEN MA INC. | 2006-03-23 | — | — | US | claimed |
| WO-2006026306-A1 | PYRIMIDINYLIMIDAZOLES AS TGF-BETA INHIBITORS | BIOGEN IDEC MA INC. (US) | 2006-03-09 | — | — | WO | claimed |
| EP-1578425-A1 | SUBSTITUTED 1-PIPERIDIN-3-YL-4-PIPERIDIN-4-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-09-28 | — | — | EP | claimed |
| EP-1499308-A2 | TRI-SUBSTITUTED HETEROARYLS AND METHODS OF MAKING AND USING THE SAME | BIOGEN, INC. (US) | 2005-01-26 | — | — | EP | claimed |
| WO-2004056364-A1 | SUBSTITUTED 1-PIPERIDIN-3-YL-4-PIPERIDIN-4-YL-PIPERAZINE DERIVATIVES AND THEIR USE AS NEUROKININ ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-07-08 | — | — | WO | claimed |
| WO-2003087304-A2 | TRI-SUBSTITUTED HETEROARYLS AND METHODS OF MAKING AND USING THE SAME | BIOGEN, INC. (US) | 2003-10-23 | — | — | WO | claimed |
| US-10155763-B2 | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | TIUMBIO CO., LTD. (KR) | 2018-12-18 | — | — | US | disclosed |
| WO-2002098424-A1 | NOVEL ANTI-INFECTIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-12-12 | — | — | WO | disclosed |