Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 17/20 | 0.70 |
| ▸ | BCL2L1 | Q07817 | 17/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9951669 | 0.94 | BCL2 (0.67) | BCL2BCL2L1 | |
| SCHEMBL9951520 | 0.91 | BCL2 (0.67) | BCL2BCL2L1 | |
| SCHEMBL10166317 | 0.87 | BCL2 (0.62) | BCL2BCL2L1 | |
| SCHEMBL15338146 | 0.87 | BCL2 (0.62) | BCL2BCL2L1 | |
| SCHEMBL9952554 | 0.87 | BCL2 (0.93) | BCL2BCL2L1 | |
| SCHEMBL9952562 | 0.87 | BCL2 (0.93) | BCL2BCL2L1 | |
| SCHEMBL15327644 | 0.85 | BCL2 (0.84) | BCL2BCL2L1 | |
| SCHEMBL9951471 | 0.85 | BCL2 (0.84) | BCL2BCL2L1 | |
| SCHEMBL10166332 | 0.85 | BCL2 (0.64) | BCL2BCL2L1 | |
| SCHEMBL9951461 | 0.84 | BCL2 (0.64) | BCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475661-B1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2013-10-23 | — | — | EP | disclosed |