Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 17/20 | 0.62 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | BCL2 | P10415 | 13/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2687027 | 0.83 | BCL2L1 (0.42) | BCL2L1BCL2 | |
| SCHEMBL9951162 | 0.80 | BCL2L1 (0.43) | BCL2L1BCL2BAD | |
| SCHEMBL2405717 | 0.78 | BCL2L1 (0.60) | BCL2L1CASRBCL2 | |
| SCHEMBL554095 | 0.77 | BCL2L1 (1.00) | BCL2L1BCL2 | |
| SCHEMBL30777653 | 0.77 | BCL2L1 (1.00) | BCL2L1BCL2 | |
| SCHEMBL554094 | 0.77 | BCL2L1 (1.00) | BCL2L1BCL2 | |
| SCHEMBL9951903 | 0.76 | BCL2 (0.45) | BCL2L1BCL2 | |
| SCHEMBL25423836 | 0.74 | BCL2L1 (0.94) | BCL2L1BCL2 | |
| SCHEMBL25423839 | 0.74 | BCL2L1 (0.94) | BCL2L1BCL2 | |
| SCHEMBL29843098 | 0.74 | BCL2L1 (0.77) | BCL2L1BCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475661-B1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2013-10-23 | — | — | EP | disclosed |