Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 20/20 | 0.87 |
| ▸ | BCL2L1 | Q07817 | 15/20 | 0.87 |
| ▸ | BCL2L2 | Q92843 | 3/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327755 | 1.00 | BCL2 (0.87) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951020 | 0.93 | BCL2 (1.00) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951027 | 0.93 | BCL2 (1.00) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951296 | 0.91 | BCL2 (0.83) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951300 | 0.91 | BCL2 (0.83) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9952489 | 0.90 | BCL2 (0.82) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9952482 | 0.90 | BCL2 (0.82) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951694 | 0.90 | BCL2 (0.94) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951277 | 0.90 | BCL2 (0.81) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL9951285 | 0.90 | BCL2 (0.81) | BCL2BCL2L1BCL2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2475661-B1 | SULFONAMIDES AS INHIBITORS OF BCL-2 FAMILY PROTEINS FOR THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2013-10-23 | — | — | EP | disclosed |