Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 20/20 | 0.82 |
| ▸ | PIM3 | Q86V86 | 20/20 | 0.82 |
| ▸ | PIM2 | Q9P1W9 | 20/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15327756 | 1.00 | PIM1 (0.82) | PIM1PIM3PIM2 | |
| SCHEMBL2694153 | 0.90 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2694159 | 0.90 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2692560 | 0.83 | PIM2 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL2692564 | 0.83 | PIM2 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL3225622 | 0.79 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL3225631 | 0.79 | PIM1 (1.00) | PIM1PIM3PIM2 | |
| SCHEMBL12687517 | 0.78 | PIM1 (0.78) | PIM1PIM3PIM2 | |
| SCHEMBL4122477 | 0.77 | PIM2 (0.90) | PIM1PIM3PIM2 | |
| SCHEMBL16754173 | 0.76 | PIM1 (0.75) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2262802-B1 | PIM KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG (CH) | 2013-10-23 | — | — | EP | claimed |