Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | VCP | P55072 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.70 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | HBB | P68871 | 2/20 | 0.53 |
| ▸ | PNP | P00491 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | EDNRA | P25101 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8981323 | 0.91 | BLM (0.62) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15328847 | 0.88 | PDE3A (0.69) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15329058 | 0.88 | PDE3A (0.68) | BLMMEN1KMT2AALDH1A1LMNA | |
| Acetic Acid SCHEMBL8981269 | 0.88 | PDE3A (0.59) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15328855 | 0.88 | PDE3A (0.68) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15339174 | 0.87 | PDE3A (0.73) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL5555694 | 0.85 | PDE3A (0.79) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL15328863 | 0.85 | PDE3A (0.62) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL9584264 | 0.85 | PDE3A (0.84) | BLMMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL10814261 | 0.85 | PDE3A (0.78) | BLMMEN1KMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104394868-A | Cyclopropane carboxylic acid esters of purine analogs | ANNJI PHARM CO LTD | 2015-03-04 | — | — | CN | claimed |
| US-20130281517-A1 | CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-24 | — | — | US | claimed |
| EP-2838538-B1 | CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES | ANNJI PHARM CO LTD (CN) | 2017-03-15 | — | — | EP | disclosed |
| CN-104394868-A | Cyclopropane carboxylic acid esters of purine analogs | ANNJI PHARM CO LTD | 2015-03-04 | — | — | CN | disclosed |
| US-8969361-B2 | Cyclopropanecarboxylate esters of purine analogues | Annji Pharmaceutical Co., Ltd. (TW) | 2015-03-03 | — | — | US | disclosed |
| US-8969361-B2 | Cyclopropanecarboxylate esters of purine analogues | Annji Pharmaceutical Co., Ltd. (TW) | 2015-03-03 | — | — | US | disclosed |
| US-8969361-B2 | Cyclopropanecarboxylate esters of purine analogues | Annji Pharmaceutical Co., Ltd. (TW) | 2015-03-03 | — | — | US | disclosed |
| US-20130281517-A1 | CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-24 | — | — | US | disclosed |
| US-20130281517-A1 | CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-24 | — | — | US | disclosed |
| US-20130281517-A1 | CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES | Annji Pharmaceutical Co., Ltd. (TW) | 2013-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130281517-A1 | CYCLOPROPANECARBOXYLATE ESTERS OF PURINE ANALOGUES | TYMP, PNP, PAICS | BLM 1087/4885MEN1 2589/4885KMT2A 3707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.