SCHEMBL15329903

SCHEMBL15329903

CCCc1nn(-c2ccc(Br)cc2)c(Cl)c1C=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.38
MEN1 O00255 3/20 0.38
KMT2A Q03164 3/20 0.38
ALDH1A1 P00352 2/20 0.38
PTGS2 P35354 3/20 0.33
NPC1 O15118 1/20 0.33
RAB9A P51151 1/20 0.33
CA12 O43570 2/20 0.33
CA1 P00915 2/20 0.33
CA2 P00918 2/20 0.33
CA9 Q16790 2/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
CCNE2 O96020 1/20 0.32
CCNE1 P24864 1/20 0.32
CDK2 P24941 1/20 0.32
STAT3 P40763 1/20 0.32
STAT1 P42224 1/20 0.32
LMNA P02545 1/20 0.32
RECQL P46063 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15331734 0.89 MAPT (0.40) MAPTMEN1KMT2AALDH1A1PTGS2
SCHEMBL15330703 0.89 MAPT (0.40) MAPTMEN1KMT2AALDH1A1PTGS2
SCHEMBL15332498 0.88 MAPT (0.40) MAPTMEN1KMT2AALDH1A1PTGS2
SCHEMBL15331272 0.86 MAPT (0.43) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL29956741 0.86 SMN1; SMN2 (0.45) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL29958073 0.85 SMN1; SMN2 (0.33) MAPTMEN1KMT2AALDH1A1NPC1
SCHEMBL15330043 0.85 KMT2A (0.39) MAPTMEN1KMT2AALDH1A1RAB9A
SCHEMBL2557973 0.83 MAPT (0.38) MAPTMEN1KMT2AALDH1A1PTGS2
SCHEMBL2558172 0.83 GAA (0.39) MAPTALDH1A1GAAL3MBTL1GLP1R
SCHEMBL15330522 0.81 MAPT (0.42) MAPTMEN1KMT2AALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-11225655-B2 Bi-functional complexes and methods for making and using such complexes NUEVOLUTION A/S (DK) 2022-01-18 US disclosed
EP-3540059-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES Nuevolution A/S (DK) 2019-09-18 EP disclosed
EP-2558577-B1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION AS (DK) 2018-12-12 EP disclosed
US-20130281324-A1 BI-FUNCTINAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2013-10-24 US disclosed