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SCHEMBL15345283

SCHEMBL15345283

COc1c(C(C)(C)C)cc2c(c1-c1ccccc1)C=C(CC(C)C)C2[Zr]([SiH3])(Cl)(Cl)C1C(CC(C)C)=Cc2c1cc(C(C)(C)C)c(OC)c2-c1ccccc1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ PDE4A P27815 2/20 0.33
▸ PDE4B Q07343 2/20 0.33
▸ PDE4C Q08493 2/20 0.33
▸ PDE4D Q08499 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2595789 0.88 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
SCHEMBL9960059 0.88 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL15345341 0.87 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL28779170 0.82 PDE4A (0.35) PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL28779171 0.82 PDE4A (0.35) PDE4APDE4BPDE4CPDE4D
SCHEMBL9960113 0.82 PDE4A (0.34) PDE4APDE4BPDE4CPDE4D
SCHEMBL15424253 0.82 PDE4A (0.34) PDE4APDE4BPDE4CPDE4D
Hydrochloric Acid SCHEMBL15345284 0.80 PDE4A (0.33) PDE4APDE4BPDE4CPDE4D
SCHEMBL15411135 0.80 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D
SCHEMBL9960097 0.79 PDE4A (0.32) PDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2657285-B1 moulded polypropylene with high content of beta form BOREALIS AG (AT) 2015-07-22 — — EP disclosed
EP-2657285-A1 Moulded polypropylene with high content of beta form Borealis AG (AT) 2013-10-30 — — EP disclosed