Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 18/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1428780 | 0.86 | JAK2 (0.51) | JAK2KCNH2JAK3KDM4EALDH1A1 | |
| SCHEMBL15375393 | 0.79 | JAK2 (0.38) | JAK2KCNH2JAK3 | |
| SCHEMBL3678337 | 0.75 | JAK2 (0.64) | JAK2KCNH2JAK3 | |
| SCHEMBL3672820 | 0.74 | JAK2 (0.60) | JAK2KCNH2JAK3 | |
| SCHEMBL15375458 | 0.74 | JAK2 (0.46) | JAK2KCNH2JAK3 | |
| SCHEMBL12801179 | 0.74 | JAK2 (0.37) | JAK2KCNH2JAK3KDM4EALDH1A1 | |
| SCHEMBL3674505 | 0.73 | JAK2 (0.45) | JAK2KCNH2JAK3 | |
| SCHEMBL1430446 | 0.73 | JAK2 (0.52) | JAK2KCNH2JAK3 | |
| SCHEMBL3670599 | 0.72 | JAK2 (0.46) | JAK2KCNH2JAK3 | |
| SCHEMBL3668776 | 0.72 | JAK2 (0.42) | JAK2KCNH2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2299816-B1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME (US) | 2013-11-13 | — | — | EP | disclosed |