Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | HPN | P05981 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1109409 | 0.92 | MEN1 (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL15375601 | 0.90 | MEN1 (0.45) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL406216 | 0.89 | MEN1 (0.44) | MEN1KMT2A | |
| SCHEMBL1195831 | 0.88 | MEN1 (0.50) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL405451 | 0.86 | MEN1 (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL1109208 | 0.83 | MEN1 (0.47) | MEN1KMT2APDE4APDE4BPDE4C | |
| SCHEMBL1912285 | 0.81 | MEN1 (0.43) | MEN1KMT2AGAAALDH1A1LMNA | |
| SCHEMBL404696 | 0.80 | MEN1 (0.45) | MEN1KMT2A | |
| SCHEMBL1109373 | 0.80 | MEN1 (0.44) | MEN1KMT2AALDH1A1LMNAKDM4E | |
| SCHEMBL1912158 | 0.79 | MEN1 (0.54) | MEN1KMT2APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2662353-A2 | Antibacterial agents | Achaogen, Inc. (US) | 2013-11-13 | — | — | EP | disclosed |