Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15380749 | 0.96 | GPBAR1 (0.56) | GPBAR1NR1H4 | |
| Hydrochloric Acid SCHEMBL15380557 | 0.95 | GPBAR1 (0.55) | GPBAR1NR1H4 | |
| SCHEMBL15380665 | 0.93 | GPBAR1 (0.47) | GPBAR1 | |
| SCHEMBL1982118 | 0.88 | GPBAR1 (0.61) | GPBAR1NR1H4 | |
| Bromide SCHEMBL1982231 | 0.87 | GPBAR1 (0.60) | GPBAR1NR1H4 | |
| SCHEMBL15380312 | 0.86 | GPBAR1 (0.58) | GPBAR1NR1H4 | |
| SCHEMBL12593307 | 0.85 | GPBAR1 (0.55) | GPBAR1NR1H4 | |
| SCHEMBL1981797 | 0.85 | GPBAR1 (0.56) | GPBAR1NR1H4 | |
| SCHEMBL15382939 | 0.85 | GPBAR1 (0.56) | GPBAR1NR1H4 | |
| Hydrochloric Acid SCHEMBL1985845 | 0.85 | GPBAR1 (0.59) | GPBAR1NR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846739-B2 | TGR5 agonists | EXELIXIS PATENT COMPANY LLC (US) | 2014-09-30 | — | — | US | claimed |
| US-20130303505-A1 | TGR5 AGONISTS | EXELIXIS PATENT COMPANY LLC | 2013-11-14 | — | — | US | claimed |
| US-8846739-B2 | TGR5 agonists | EXELIXIS PATENT COMPANY LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8846739-B2 | TGR5 agonists | EXELIXIS PATENT COMPANY LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130303505-A1 | TGR5 AGONISTS | EXELIXIS PATENT COMPANY LLC | 2013-11-14 | — | — | US | disclosed |
| US-20130303505-A1 | TGR5 AGONISTS | EXELIXIS PATENT COMPANY LLC | 2013-11-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130303505-A1 | TGR5 AGONISTS | GCGR, NPY5R, TBXA2R | GPBAR1 12/4885NR1H4 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.