SCHEMBL15397495

SCHEMBL15397495

CN(C(=O)N(C)[C@@H]1CN(C(=O)C2CCC(NC(=O)O)CC2)C[C@H]1c1ccc(F)cc1)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.85

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 20/20 0.85
TACR2 P21452 12/20 0.85
TACR3 P29371 11/20 0.85
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
TAC3 Q9UHF0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15397600 1.00 TACR1 (0.85) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL15397494 1.00 TACR1 (0.85) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL15397477 0.96 TACR1 (0.79) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL15397476 0.96 TACR1 (0.79) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL15397607 0.95 TACR3 (0.77) TACR1TACR2TACR3
SCHEMBL15397468 0.95 TACR1 (0.77) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL15397469 0.95 TACR1 (0.77) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL15397606 0.95 TACR3 (0.77) TACR1TACR2TACR3
SCHEMBL1968578 0.94 TACR1 (0.86) TACR1TACR2TACR3CYP3A4CYP2D6
SCHEMBL1968581 0.94 TACR1 (0.86) TACR1TACR2TACR3CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE49686-E1 Nitrogen-containing heterocyclic compound and use of same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2023-10-10 US disclosed
US-RE48334-E1 Nitrogen-containing heterocyclic compound and use of same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2020-12-01 US disclosed
EP-2336105-B9 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE OF SAME TAKEDA PHARMACEUTICAL (JP) 2014-09-17 EP disclosed
EP-2336105-B1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE OF SAME TAKEDA PHARMACEUTICAL (JP) 2014-02-12 EP disclosed
US-8592454-B2 Nitrogen-containing heterocyclic compound and use of same TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2013-11-26 US disclosed